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Related Experiment Videos

Disseminated cutaneous leishmaniasis.

Khalifa E Sharquie1, Rafid A Najim

  • 1Department of Dermatology, College of Medicine, University of Baghdad, Baghdad, Iraq.

Saudi Medical Journal
|July 6, 2004
PubMed
Summary

Disseminated cutaneous leishmaniasis (DCL) is rare in the Middle East. Oral zinc sulfate effectively treated a patient with DCL, showing complete lesion clearance and no recurrence after treatment.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Parasitology

Background:

  • Disseminated cutaneous leishmaniasis (DCL) is a rare manifestation of Leishmania infection.
  • The Middle East rarely reports cases of DCL, making this case noteworthy.

Observation:

  • A 60-year-old female presented with facial nodules consistent with DCL, initially appearing in 1996.
  • Histopathology revealed macrophages laden with Leishmania-Donovan (L-D) bodies.
  • The patient experienced a relapse in 2003 with similar lesions.

Findings:

  • Oral zinc sulfate (10 mg/kg/day) led to gradual improvement and complete clearance of DCL lesions within 6 months.
  • Histopathological examination confirmed resolution of amastigotes.
  • A subsequent 4-month course of zinc sulfate achieved complete clearance after relapse.

Implications:

  • Zinc sulfate demonstrates potential as a novel therapeutic agent for DCL.
  • This finding is significant given the current lack of adequate treatments for DCL.
  • Further research into zinc sulfate's efficacy for DCL is warranted.

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