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Updated: Aug 23, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
[Relevant factors influencing the evolution of 206 patients with severe head injury]
Venâncio Pereira Dantas Filho1, Antonio Luis Eiras Falcão, Luis Antonio da Costa Sardinha
1Departamento de Neurologia e Neurocirurgia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil. venancio@hc.unicamp.br
Abstract:
The search for head injury prognostic factors has been intense in the last decades. The importance of identification of these factors has been also recognised to treatment orientation and results estimatives. Based on 206 severe head injuried patients series, we analyzed the influence of factors over the outcome. The initial severity by Glasgow coma scale, the presence of intracranial hypertension (over 20 mmHg), the type of intracranial lesion and the presence of hypoxia, systemic hypotension or both, significantly influenced the results. The presence of multiple traumas (at least two sites of lesion over head injury), as age, did not influence the final results in this series.
