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Continuous infusion of vecuronium in children

H Obara1, H Hoshina, O Tanaka

  • 1Department of Anesthesiology, Kobe University School of Medicine, Kobe, Japan.

Journal of Anesthesia
|March 1, 1988
PubMed

Insights

Vecuronium infusion rates were determined for children undergoing anesthesia. Higher doses were needed with halothane compared to enflurane, with no cumulative effects observed.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Neuromuscular blocking agents are crucial in pediatric anesthesia.
  • Vecuronium is commonly used, but its optimal infusion rates in children require precise determination.

Purpose of the Study:

  • To determine the average dose of vecuronium required for a 90% steady-state neuromuscular block in children via continuous infusion.
  • To compare vecuronium requirements and recovery times under enflurane and halothane anesthesia.

Main Methods:

  • Simultaneous recording of electromyographic (EMG) and mechanical responses to ulnar nerve stimulation.
  • Continuous infusion of vecuronium to achieve and maintain a 90% block.
  • Measurement of steady-state infusion rates and spontaneous recovery times.

Main Results:

  • A significant correlation was found between EMG and mechanical responses.
  • Steady-state infusion rates were 1.4 +/- 0.03 micro g/kg/min with enflurane and 3.1 +/- 0.03 micro g/kg/min with halothane.
  • Spontaneous recovery times to 25% of control were 10.3 +/- 1.5 min (enflurane) and 12.6 +/- 1.1 min (halothane).
  • No cumulative effect of vecuronium was observed after prolonged infusion.

Conclusions:

  • Vecuronium infusion requirements differ significantly between enflurane and halothane anesthesia in children.
  • The drug exhibits no cumulative effects, allowing for predictable recovery.
  • These findings aid in optimizing neuromuscular blockade management in pediatric surgical patients.

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