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5-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis.

Ram Reifen1, Andreea Nissenkorn, Zippora Matas

  • 1The School of Nutritional Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.

Journal of Gastroenterology
|July 6, 2004
PubMed
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Iron supplementation worsens colitis in rats by increasing oxidative stress. Combining iron with 5-aminosalicylic acid (5-ASA) or lycopene reduces this damage, suggesting a safer approach for patients.

Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease Research
  • Oxidative Stress Mechanisms

Background:

  • Inflammatory bowel disease (IBD) management often involves 5-aminosalicylic acid (5-ASA) and iron supplementation.
  • Both therapeutic and dietary iron can exacerbate oxidative stress in colitis.
  • The interplay between iron, 5-ASA, and antioxidants in colitis requires further investigation.

Purpose of the Study:

  • To investigate the impact of iron supplementation on colitis histology and oxidative status.
  • To evaluate the protective effects of 5-ASA and antioxidants (lycopene, beta-carotene) against iron-induced colitis.

Main Methods:

  • A rat model of colitis was induced using iodoacetamide.
  • Rats received diets with varying combinations of iron, 5-ASA, lycopene, and beta-carotene.

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  • Inflammatory markers (MPO), lipid peroxidation (MDA), and antioxidant status (SOD) were assessed.

    • Main Results:

    • Iron supplementation significantly increased colitis severity, including necrosis, ulceration, and hemorrhage.
    • Co-administration of 5-ASA and/or lycopene attenuated iron-induced mucosal damage.
    • Beta-carotene provided no significant protective benefit.

    Conclusions:

    • Iron supplementation exacerbates inflammation and mucosal damage in colitis, likely via increased oxidative stress.
    • 5-ASA and lycopene mitigate the adverse effects of iron in colitis.
    • Concurrent administration of iron with 5-ASA or lycopene is recommended to minimize potential harm.