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Updated: Aug 23, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
Published on: January 13, 2018
Effects of nitrous oxide on single breath induction with enflurane
S J Rowbottom1, H Yukioka, M Fujimori
1Department of Anesthesiology and Intensive Care Medicine, Osaka City University Medical School, Osaka, Japan.
Abstract:
A single vital capacity breath method of inhalational induction using 4% enflurane in 67% nitrous oxide (group I) or 100% oxygen (group II) was studied in 30 patients. Nitrous oxide accelerated induction time (71 (22 SD) seconds in group I versus 136 (29 SD) in group II, P = 0.01) and was associated with a decreased incidence of excitement and respiratory disturbance ( P = 0.05). There were no significant differences between groups in systolic blood pressure, heart rate or arterial oxygen saturation. The technique was acceptable to 87% in group I and 33% in group II ( P = 0.02).
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