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Screening for dihydropyridine calcium channel blockers in plasma by automated solid-phase extraction and liquid
Claudia A Mueller1, Ana B Baranda González, Wolfgang Weinmann
1Institute of Legal Medicine, Forensic Toxicology, University Hospital, Albertstrasse 9, D-79104 Freiburg, Germany. muellerc@ukl.uni-freiburg.de
Abstract:
A liquid chromatographic/tandem mass spectrometric (LC/MS/MS) screening method was developed for the screening of 11 calcium channel blockers of the 1,4-dihydropyridine type in plasma samples for forensic and clinical cases. Plasma samples were extracted by automated solid-phase extraction. Analysis was performed using a reversed-phase C(18) column, gradient elution and a triple-quadrupole mass spectrometer with TurboIonSpray source in positive mode and multiple reaction monitoring. This method was found to be selective and sensitive for the detection of the target compounds at their therapeutic plasma concentrations.
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