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Published on: February 15, 2017
Sample size and power for McNemar's test with clustered data
1Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, U.S.A. gonenm@mskcc.org
Abstract:
McNemar's test is used to compare the distribution of two paired binary random variables. When the data are clustered adjustment is needed to ensure that it is still a valid test. This article presents two approximations for calculating the power and sample size for the adjusted McNemar's test for clustered data, working with a particular adjustment. A simulation study is conducted to demonstrate the accuracy of these approximations. The method is also applied to the design of a study involving positron emission tomography in detecting metastatic colorectal cancer and sensitivity of sample size computations to the design parameters are explored in this context.
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