Related Experiment Video
Updated: Aug 23, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
Published on: September 6, 2012
Release from polymeric prodrugs: linkages and their degradation
Ajit Joseph M D'Souza1, Elizabeth M Topp
1Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Ave., Lawrence 66047, USA. adsouza@ku.edu
Abstract:
Polymeric prodrugs have evolved into a very useful class of drug delivery agents. Numerous polymeric prodrugs have been prepared for applications ranging from passive drug targeting to controlled release. The mechanistic aspects of the release processes, however, have not been clearly delineated. This review highlights the salient features of the chemical reactions that are responsible for drug release from these systems. The mechanisms of release from polymeric prodrugs employing various chemical linkages, esters, carbonates, carbamates, C=N linkage and amides, are discussed.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Stimuli-Activated
Modified-Release Drug Delivery Systems: Rate-Programmed II
Modified-Release Drug Delivery Systems: Classification
Prodrugs
Prodrugs help overcome...
Modified-Release Drug Delivery Systems: Influencing Factors

