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Polyethylene glycol electrolyte solution (Isocolan) for constipation during pregnancy: an observational open-label
Isabella Neri1, Immacolata Blasi, Paola Castro
1Clinica Ostetrica, Modena, Italy. neri.Isabella@unimore.it
Journal of Midwifery & Women'S Health
|July 9, 2004
Summary
Polyethylene glycol electrolyte solution (PEG-4000) effectively treats constipation in pregnant women. This study found PEG-4000 significantly increased bowel movements and resolved constipation in 73% of participants.
Area of Science:
- Obstetrics and Gynecology
- Gastroenterology
- Pharmacology
Background:
- Constipation is a common issue during pregnancy.
- Existing treatments may have safety concerns for pregnant individuals.
Purpose of the Study:
- To assess the efficacy and safety of polyethylene glycol electrolyte solution (PEG-4000) for treating constipation in pregnant women.
- To evaluate the impact of PEG-4000 on constipation symptoms and bowel regularity.
Main Methods:
- A preliminary study involving 40 pregnant women (6-38 weeks' gestation) with constipation.
- Participants received PEG-4000 (250 mL) orally once or twice daily for 15 days.
- Evaluated bowel movement frequency and constipation-related symptoms before and after treatment.
Main Results:
- PEG-4000 significantly increased weekly bowel movements (1.66 to 3.16; P <.01).
- Constipation resolved in 73% (27/37) of women.
- Significant improvements were observed in defecation pain, anal injury, and abdominal pain.
Conclusions:
- Polyethylene glycol electrolyte solution (PEG-4000) appears to be an effective and safe option for managing constipation during pregnancy.
- The benefits were noted in both new-onset and pre-existing constipation cases.