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Longitudinal cerebral perfusion decrease in mild alzheimer's disease revealed by SPECT with statistical parametric

Yi-Chung Lee1, Ren-Shyan Liu, Yi-Chu Liao

  • 1The Neurological Institute, Taipei Veterans General Hospital, Section of Neurology, #201 Section 2 Shih-Pai Road, Shih-pai, Taipei 11217, Taiwan.

European Neurology
|July 9, 2004
PubMed
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Mild Alzheimer's disease patients showed reduced cerebral perfusion in temporal and fusiform gyri over time. Specific cognitive functions correlated with brain activity in these regions, highlighting regional changes in early Alzheimer's disease.

Area of Science:

  • Neuroimaging
  • Neurology
  • Cognitive Science

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
  • Early detection and understanding of regional brain changes are crucial for AD management.
  • Technetium-99m hexamethylpropylene amine oxime (HMPAO) SPECT imaging can assess cerebral blood flow.

Purpose of the Study:

  • To investigate changes in cerebral perfusion in patients with mild Alzheimer's disease over time.
  • To explore the correlation between cognitive function and regional cerebral perfusion.

Main Methods:

  • Fifteen patients with mild Alzheimer's disease underwent baseline and follow-up SPECT scans.
  • Neuropsychological assessments, including the Cognitive Ability Screening Instruments (CASI), were performed.

Related Experiment Videos

  • Voxel-based statistical parametric mapping (SPM) analyzed SPECT image differences.

    • Main Results:

    • Follow-up SPECT revealed significantly reduced cerebral perfusion in the left superior/middle temporal gyri, right middle/inferior temporal gyri, and right fusiform gyrus compared to baseline.
    • A significant correlation was found between list-generating fluency (CASI sub-score) and left fusiform gyrus perfusion.
    • Visual construction (CASI sub-score) correlated significantly with right superior/medial frontal gyri perfusion.

    Conclusions:

    • Mild Alzheimer's disease is associated with progressive decline in cerebral perfusion in specific temporal and frontal brain regions.
    • Cognitive deficits in fluency and visual construction are linked to reduced perfusion in corresponding brain areas.
    • SPECT imaging combined with neuropsychological testing can identify regional brain changes in early AD.