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Updated: Aug 19, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Human papillomavirus and extragenital in situ carcinoma
G Quéreux1, J M N'Guyen, B Dreno
1Department of Dermatology, Hôtel-Dieu, CHU, Nantes, France.
Background:
The relation between human papillomavirus (HPV) and extragenital Bowen's disease (BD) is controversial.
Methods:
This study used in situ hybridisation to evaluate the rate of HPV in extragenital cutaneous BD and investigated possible relations with immune status and exposure of skin to light.
Results:
HPV DNA was detected in 58% of 69 samples from 50 patients. The percentage of HPV detection was not significantly higher in exposed (55%) than unexposed areas (65%), and no difference in HPV rate was found between immunosuppressed and immunocompetent patients.
Conclusion:
Thus, this study confirms the high rate of HPV detection in extragenital cutaneous BD and suggests that there is no apparent relation concerning exposed areas and immune status.
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