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Published on: October 12, 2017

High remnant lipoprotein levels in patients with variant angina

Kunihisa Miwa1, Toshinori Makita, Katsuhisa Ishii

  • 1Second Department of Internal Medicine, Kansai Electric Power Hospital, Osaka, Japan. ku-miwa@hamamatsuh.go.jp

Clinical Cardiology
|July 9, 2004
PubMed

Insights

Patients with active coronary vasospasm show higher remnant lipoprotein (RLP) levels and lower alpha-tocopherol, indicating disordered lipid metabolism and oxidative stress contribute to this condition.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Oxidative Stress

Background:

  • Dyslipidemia with increased oxidative stress, independent of LDL cholesterol, is implicated in coronary vasospasm pathogenesis.
  • Triglyceride-rich lipoprotein metabolism disorders may contribute to coronary artery spasm development.

Purpose of the Study:

  • To investigate the association between remnant lipoprotein (RLP) levels, alpha-tocopherol, and variant angina (VA) activity.
  • To explore the role of disordered triglyceride-rich lipoprotein metabolism and oxidative stress in coronary vasospasm.

Main Methods:

  • Serum remnant lipoprotein (RLP) and alpha-tocopherol levels were measured in patients with active VA, inactive VA, and control subjects.
  • Triglyceride, HDL cholesterol, and smoking prevalence were also assessed and compared among groups.

Main Results:

  • Active VA patients exhibited significantly higher RLP levels and lower alpha-tocopherol levels compared to inactive VA and control groups.
  • Higher RLP levels correlated positively with triglyceride levels and inversely with alpha-tocopherol.
  • Smoking was more prevalent in active VA patients.

Conclusions:

  • Active variant angina is associated with elevated RLP levels and reduced antioxidant capacity (alpha-tocopherol).
  • Disordered triglyceride-rich lipoprotein metabolism and increased oxidative stress are linked to coronary vasospasm activity and pathogenesis.
Abstract

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