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Related Experiment Videos

Anaphylaxis to wheat beer.

Thomas Herzinger1, Gerold Kick, Dagmar Ludolph-Hauser

  • 1Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilian-University, Munich, Germany. Thomas.Herzinger@lrz.uni-muenchen.de

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|July 9, 2004
PubMed
Summary

Severe allergic reactions to beer are rare, but this case highlights wheat allergy as a potential cause. Wheat beer can trigger anaphylaxis in susceptible individuals, distinct from barley allergies.

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Area of Science:

  • Food allergy research
  • Clinical immunology
  • Gastroenterology

Background:

  • Anaphylaxis from beer consumption is uncommon.
  • Barley malt is a known, though infrequent, allergen in beer.
  • Wheat's role in beer-induced anaphylaxis has not been previously documented.

Observation:

  • A 59-year-old man experienced severe anaphylaxis, including angioedema, urticaria, and loss of consciousness, after drinking wheat beer.
  • The patient tolerated lager beer, which contains barley malt, without adverse effects.
  • Diagnostic tests included skin prick tests, oral challenges, and specific IgE antibody detection.

Findings:

  • Skin prick tests were positive for wheat beer and wheat malt, but negative for baker's yeast, hops, and lager beer.

Related Experiment Videos

  • Oral challenges with wheat beer and wheat flour induced urticarial reactions.
  • Specific IgE antibodies were detected against wheat and barley flour, with immunoblotting showing IgE binding to a ~35 kDa wheat protein.

    • Implications:

    • This case establishes wheat allergy as a cause of beer-induced anaphylaxis.
    • Clinicians should consider wheat as an allergen in patients with unexplained anaphylaxis after beer consumption.
    • Further research is needed to identify specific wheat allergens involved in beer-induced reactions.