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Published on: October 1, 2019
A diversity-oriented strategy for the construction of tetrasubstituted pyrroles via coupled domino processes
David Tejedor1, David González-Cruz, Fernando García-Tellado
1Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Avenida Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Canary Islands, Spain.
Abstract:
A new microwave-assisted rearrangement of 1,3-oxazolidines scaffolds is the basis for a new, metal-free, direct, and modular construction of tetrasubstituted pyrroles from terminal-conjugated alkynes, aldehydes, and primary amines. This new reaction manifold entails two linked domino processes in a one-pot manner with both atom- and bond-efficiency and under very simple and environment-friendly experimental conditions.
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