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Chronic Intestinal Pseudoobstruction.

Greg Lyford¹, Amy Foxx-Orenstein

¹Clinical Enteric Neuroscience Translational and Epidemiologic Research Program (C.E.N.T.E.R.), Enteric Neuroscience Program, Charlton 8, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA. foxx-orenstein.amy@mayo.edu

Current Treatment Options in Gastroenterology

|July 9, 2004

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Chronic intestinal pseudoobstruction (CIP) management involves various therapies to improve quality of life, as no cure exists. Optimal care requires a supportive network addressing nutritional and symptom management for patients with this condition.

Area of Science:

Gastroenterology
Internal Medicine

Background:

Chronic intestinal pseudoobstruction (CIP) presents with debilitating symptoms like abdominal pain and nausea, significantly impacting patient quality of life.
Currently, no definitive cure for CIP exists, necessitating diverse management strategies.

Purpose of the Study:

To outline current management strategies for chronic intestinal pseudoobstruction (CIP).
To emphasize the importance of a comprehensive, supportive care network for CIP patients.

Main Methods:

Review of pharmacologic agents (e.g., prokinetics, octreotide) for symptom control and transit promotion.
Discussion of nutritional support including enteral feeding and total parenteral nutrition (TPN).
Consideration of endoscopic and surgical interventions, including small intestinal transplantation, with associated risks.

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Main Results:

Pharmacologic interventions like prokinetic agents and octreotide can alleviate acute symptoms and stimulate motility.
Nutritional support, including TPN, is crucial for patients unable to tolerate oral intake, despite associated complications.
Surgical options, such as resection and transplantation, are high-risk and reserved for specific cases, requiring careful consideration.

Conclusions:

Effective management of CIP requires a multimodal approach combining pharmacologic, nutritional, endoscopic, and surgical interventions.
Addressing nutritional challenges and symptom control is paramount for improving patient outcomes.
Establishing a supportive healthcare network is essential for comprehensive CIP patient care.