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Activation of coagulation system in dilated cardiomyopathy: comparison of patients with and without left ventricular

Ali Riza Erbay1, Hasan Turhan, Yuksel Aksoy

  • 1Turkiye Yuksek Ihtisas Hospital Department of Cardiology, Ankara, Turkey.

Coronary Artery Disease
|July 9, 2004
PubMed

Insights

Platelet activation, thrombin activation, and fibrinolysis are elevated in dilated cardiomyopathy (DCM) patients compared to controls. Left ventricular thrombus presence did not alter these coagulation markers in DCM.

Area of Science:

  • Cardiology
  • Hematology
  • Biochemistry

Background:

  • Dilated cardiomyopathy (DCM) is associated with increased risk of thromboembolic events.
  • Understanding the prothrombotic state in DCM is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate plasma levels of molecular markers for platelet activity, thrombin activation, and fibrinolytic status in patients with DCM.
  • To compare these markers between DCM patients with and without left ventricular (LV) thrombus and with healthy controls.

Main Methods:

  • Sixty DCM patients (22 with LV thrombus, 38 without) and 23 healthy controls were included.
  • Plasma levels of platelet markers (PF4, beta-TG), thrombin generation markers (FpA, TAT), and fibrinolysis markers (D-dimer, PAP) were measured.
  • Comparisons were made between DCM patients and controls, and between DCM subgroups with and without LV thrombus.

Main Results:

  • Patients with DCM exhibited significantly higher levels of platelet activity markers (PF4, beta-TG) compared to controls.
  • Markers of thrombin activation (FpA, TAT) and fibrinolysis (D-dimer, PAP) were also significantly elevated in DCM patients versus controls.
  • No significant differences in these coagulation markers were observed between DCM patients with and without LV thrombus.

Conclusions:

  • Platelet activation, thrombin activation, and fibrinolytic activity are increased in patients with DCM.
  • The presence of LV thrombus in DCM does not appear to be associated with distinct alterations in these specific coagulation markers.
Abstract

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