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Synthesis and phenotypic screening of a Guanine-mimetic library

Stephen C Miller1, Timothy J Mitchison

  • 1Department of Cell Biology and Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, MA 02115, USA. smiller@hms.harvard.edu

Chembiochem : a European Journal of Chemical Biology
|July 9, 2004
PubMed
Abstract

No abstract available in PubMed .

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Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...