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Updated: Aug 23, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Chiral discrimination between thalidomide enantiomers using a solid surface with two-dimensional chirality
Takuya Nakanishi1, Naoko Yamakawa, Toru Asahi
1Department of Applied Chemistry, School of Science and Engineering, Waseda University, Tokyo, Japan.
Abstract:
Chiral discrimination between thalidomide enantiomers was achieved using the self-assembled monolayer (SAM) of an atropisomeric compound, 1,1'-binaphthalene-2,2'-dithiol (BNSH), which takes a two-dimensional chiral arrangement on gold(111) surface. Interestingly, an "all-or-none" type enantioselectivity appears; one enantiomeric form of BNSH SAM allows the adsorption of only one enantiomer of thalidomide. In addition, the response of a racemic SAM of BNSH was revealed to be one-half of that caused by pure enantiomeric SAM.
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