Related Experiment Video
Updated: Aug 23, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
[Cyclooxygenase 2 inhibitors and adenomatous polyposis coli]
Christian Florent1, Nathalie Meary
1Gastro-entérologie, Hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris.
Abstract:
Prolonged use of aspirin and/or non-steroidal anti-inflammatory drugs induces a partial regression of either sporadic adenomas or adenomas in adenomatous polyposis coli (APC), but also their emergence and colonic cancer development in sporadic adenomas. Specific inhibitors of cyclooxygenase of type 2 (Cox2) induce less upper and lower digestive tract adverse events that non-specific anti-inflammatory drugs. This better tolerance might allow a long-lasting use in patients with APC. At time, we don't know if such treatments are able to prevent the development of cancer in the rectum or duodenum of these patients. In this paper we will discuss the scientific proofs and potential interest of Cox2 inhibitors in the treatment of PAF.
More Related Videos
05:58Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
Published on: August 20, 2018
09:29Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
Related Concept Videos
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease II: Ulcerative Colitis
Drugs for Treatment of Constipation-Predominant IBS
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inhibition of Cdk Activity
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...