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Related Experiment Videos

[Urinary calcium and bone turnover markers].

José Pío X de la Torre Vega1, Norma Amador Licona, Lilia Zamora Mata

  • 1Unidad metabólica del Hospital de Especialidades, IMSS, Delegación Guanajuato.

Ginecologia Y Obstetricia De Mexico
|July 9, 2004
PubMed
Summary

In postmenopausal women, fasting urinary calcium (Ca/Cr index) correlates with parathormone and calcitonin levels. However, urinary calcium excretion after a calcium load did not correlate with bone turnover markers.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Mineral Homeostasis

Background:

  • Menopause is associated with changes in bone metabolism.
  • Understanding calcium excretion patterns is crucial for assessing bone health.

Purpose of the Study:

  • To investigate the relationship between bone turnover markers and urinary calcium excretion in premenopausal and postmenopausal women.
  • To assess the impact of oral calcium load on these relationships.

Main Methods:

  • Cross-sectional study of 100 women (50 premenopausal, 50 postmenopausal).
  • Collected 24-hour urine samples, fasting urine, and urine 4 hours post-oral calcium load.
  • Measured serum levels of bone turnover markers, calcium, parathormone, vitamin D, and urinary calcium/creatinine (Ca/Cr) index.

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Main Results:

  • Postmenopausal women exhibited lower calcitonin levels and a higher 2-hour fasting Ca/Cr index compared to premenopausal women.
  • The 2-hour fasting Ca/Cr index showed significant correlations with age, parathormone, and calcitonin levels.
  • Urinary calcium excretion, including post-calcium load, did not correlate with bone turnover markers or forearm bone mineral density.

Conclusions:

  • The 2-hour fasting urinary Ca/Cr index is a relevant indicator of parathormone and calcitonin levels in postmenopausal women.
  • Oral calcium load does not appear to influence the relationship between urinary calcium excretion and bone turnover markers.