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Updated: Aug 6, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Metastatic papillary carcinoma of the thyroid
1Quest Diagnostics Incorporated, Cambridge, MA 02139, USA. mahalinm@questdiagnostics.com
Background:
Cutaneous metastases from thyroid carcinomas, although uncommon, have been previously reported and are usually found in association with evidence of disseminated disease.
Methods:
We report a 75-year-old male who presented with a 4-cm reddish violaceous nodule on the left temple and a clinical history significant for papillary carcinoma of the thyroid.
Results:
Microscopic examination of a 4-mm punch biopsy revealed a poorly circumscribed neoplasm with focal epidermal connection and multiple cystic cavities and papillary projections.
Conclusions:
This case report describes a solitary cutaneous lesion as the first evidence of disseminated neoplastic disease in a patient with no other clinical evidence of concurrent metastases. The histology of the lesion was unusual in that it mimicked a primary cutaneous neoplasm.
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