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Related Experiment Videos

Vimentin immunoreactivity in normal and pathological human brain tissue.

T Yamada1, T Kawamata, D G Walker

  • 1Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.

Acta Neuropathologica
|January 1, 1992
PubMed
Summary

Vimentin, a protein, is highly expressed in astrocytes and microglia within diseased human brain tissues, indicating its role in central nervous system disorders like Alzheimer's disease and multiple sclerosis.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Immunohistochemistry

Background:

  • Vimentin is an intermediate filament protein found in various cell types.
  • Its role in the central nervous system (CNS) and its expression patterns in neurological diseases are not fully elucidated.

Purpose of the Study:

  • To investigate vimentin expression in human brain tissues across different neurological conditions.
  • To characterize vimentin-immunoreactivity in astrocytes and microglia in the context of CNS diseases.

Main Methods:

  • Immunohistochemistry was used to detect vimentin in post-mortem human brain tissues.
  • Tissues examined included non-neurological controls and cases of Alzheimer's disease, Pick's disease, amyotrophic lateral sclerosis, multiple sclerosis, cerebral infarction, Parkinson's disease, and progressive supranuclear palsy.

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Main Results:

  • Intense vimentin immunoreactivity was observed in ependymal cells and subpial tissues in all brains.
  • Diseased brains (Alzheimer's, Pick's, ALS, MS, infarction) showed numerous vimentin-positive astrocytes.
  • Vimentin-positive microglia/macrophages were abundant in ALS, MS, and infarction cases, and associated with senile plaques in Alzheimer's disease.

Conclusions:

  • Vimentin is upregulated in reactive astrocytes and microglia in various human central nervous system diseases.
  • These findings suggest vimentin's involvement in the neuropathological processes of these conditions.
  • Vimentin may serve as a potential biomarker for reactive glial cells in neurodegenerative and other CNS disorders.