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SPOC: a widely distributed domain associated with cancer, apoptosis and transcription
Luis Sánchez-Pulido1, Ana M Rojas, Karel H van Wely
1Protein Design Group, Centro Nacional de Biotecnología (CNB-CSIC), Cantoblanco, E-28049 Madrid, Spain. sanchez@cnb.uam.es
Background:
The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level.
Results:
We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods.
Conclusions:
The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality.
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