Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Apoptosis, subcellular particles, and autoimmunity.

Amy M Cline¹, Marko Z Radic

¹Department of Molecular Science, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.

Clinical Immunology (Orlando, Fla.)

|July 9, 2004

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial: Community series in SARS-CoV-2 variants, B lymphocytes, and autoreactivity, volume II.

Frontiers in immunology·2026

Same author

Quantifying neutrophil extracellular trap release in a combined infection-inflammation NET-array device.

Lab on a chip·2024

Same author

Editorial: SARS-CoV-2 variants, B lymphocytes, and autoreactivity.

Frontiers in immunology·2023

Same author

TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response.

Cell reports·2022

Same author

Human neutrophil FcγRIIIb regulates neutrophil extracellular trap release in response to electrospun polydioxanone biomaterials.

Acta biomaterialia·2021

Same author

Patients with COVID-19: in the dark-NETs of neutrophils.

Cell death and differentiation·2021

Same journal

A novel JAK1 mutation identified in a patient with severe atopic dermatitis phenotype: Mechanistic insights and IL-4Rα targeted therapy.

Clinical immunology (Orlando, Fla.)·2026

Same journal

VNN1 aggravates sepsis by promoting inflammation and oxidative stress through PPARγ signaling VNN1 in sepsis.

Clinical immunology (Orlando, Fla.)·2026

Same journal

Comparison between glioblastoma and brain metastases: How epigenetic remodeling can enhance immunotherapy.

Clinical immunology (Orlando, Fla.)·2026

Same journal

JAK-STAT3-MYC axis defines pathogenic stem cell-like memory CD4<sup>+</sup> T cells in rheumatoid arthritis.

Clinical immunology (Orlando, Fla.)·2026

Same journal

The baseline vaginal immune milieu is an important determinant of the inflammatory response induced by penile-vaginal sex.

Clinical immunology (Orlando, Fla.)·2026

Same journal

Adulthood diagnosis of Nijmegen breakage syndrome in twins with antibody deficiency clinical presentation.

Clinical immunology (Orlando, Fla.)·2026

See all related articles

Defects in clearing apoptotic cells heighten autoimmune disease risk. Subcellular particles, enriched with autoantigens, may play a key role in autoimmunity development.

Area of Science:

Immunology
Cell Biology
Autoimmunity

Background:

Apoptosis (programmed cell death) is linked to autoimmune disease development.
Deficiencies in clearing apoptotic cells increase autoimmunity risk.
Autoantigens are modified and exposed on cell surface blebs during apoptosis.

Purpose of the Study:

To investigate the role of subcellular particles (SCPs) in autoimmunity.
To explore the significance of autoantigen-enriched SCPs in programmed cell death.

Main Methods:

Genetic analyses of serum proteins and receptors involved in apoptotic cell clearance.
Administration of apoptotic cells to naive animals to observe immune responses.
Characterization of autoantigens within blebs and subsequent apoptotic bodies/SCPs.

Related Experiment Videos

Main Results:

Deficiencies in apoptotic cell clearance mechanisms correlate with increased autoimmunity.
Administration of apoptotic cells can induce transient autoimmune responses.
Blebs, a transient stage of apoptosis, contain autoantigens and rapidly form SCPs.

Conclusions:

Subcellular particles (SCPs) are a critical, yet understudied, component of apoptosis.
Autoantigen-enriched SCPs are proposed as significant factors in the pathogenesis of autoimmune diseases.
Further research into SCPs is crucial for understanding and potentially treating autoimmunity.