Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Consumer vinegar test for determining calcium disintegration.

N A Mason1, J D Patel, J B Dressman

  • 1College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.

American Journal of Hospital Pharmacy
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CHIO3: CHemotherapy combined with immune checkpoint inhibitor for operable stage IIIA/B (N2) Non-Small cell lung cancer (AFT-46).

Lung cancer (Amsterdam, Netherlands)·2026
Same author

Drug Permeability - Best Practices for Biopharmaceutics Classification System (BCS)-Based Biowaivers: A workshop Summary Report.

Journal of pharmaceutical sciences·2023
Same author

Relationship between efficacy outcomes and weight gain during treatment of advanced, non-squamous, non-small-cell lung cancer patients.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Comparison of canine and human gastrointestinal physiology.

Pharmaceutical research·2013
Same author

Dosing to rash: a phase II trial of the first-line erlotinib for patients with advanced non-small-cell lung cancer an Eastern Cooperative Oncology Group Study (E3503).

European journal of cancer (Oxford, England : 1990)·2013
Same author

The characterization of herbicide tolerant plants in Brassica napus L. after in vitro selection of microspores and protoplasts.

Plant cell reports·2013

A consumer vinegar test effectively predicts calcium tablet disintegration, showing strong correlation with standardized methods. However, disintegration time did not predict calcium bioavailability through dissolution testing.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery and Formulation

Background:

  • Calcium supplements are widely used, but their disintegration and dissolution properties can vary significantly.
  • Standardized methods exist for testing tablet disintegration, but consumer-friendly alternatives are also employed.

Purpose of the Study:

  • To compare a consumer-based disintegration test (using vinegar) with standardized methods for calcium tablets.
  • To evaluate if the consumer disintegration test can predict the bioavailability of calcium through dissolution testing.

Main Methods:

  • Seventeen calcium tablet products were tested for disintegration in simulated gastric fluid (GF), distilled water, and white distilled vinegar.
  • Disintegration was visually assessed over 30-60 minutes.
  • Seven products underwent dissolution testing in GF or water over 120 minutes, with calcium content measured via ion-selective electrode.

Related Experiment Videos

Main Results:

  • Consumer vinegar test results showed 87%-93% agreement with standardized disintegration tests, indicating a significant correlation.
  • Disintegration times varied widely across products and testing media.
  • No correlation was found between the disintegration time of calcium tablets and their extent of dissolution.

Conclusions:

  • The consumer vinegar disintegration test is a reliable predictor of standardized disintegration for calcium tablets.
  • Calcium tablet disintegration and dissolution exhibit high variability.
  • Disintegration testing, including the consumer method, does not reliably predict calcium bioavailability as assessed by dissolution.