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Serum osteocalcin levels in hyperthyroidism before and after antithyroid therapy
Gulhan Barsal1, Fatma Taneli, Aysenur Atay
1Biochemistry and Clinical Biochemistry Laboratory, Atatürk Training Hospital, Izmir, Turkey.
The Tohoku Journal of Experimental Medicine
|July 9, 2004
Summary
Hyperthyroidism accelerates bone turnover. This study found that bone formation and resorption markers, osteocalcin and urine calcium/creatinine, remain elevated even after treatment normalizes thyroid hormone levels.
Area of Science:
- Endocrinology
- Bone Metabolism
- Biochemistry
Background:
- Hyperthyroidism is associated with increased bone turnover due to direct thyroid hormone stimulation of bone cells.
- Understanding bone remodeling markers is crucial for managing hyperthyroid patients.
Purpose of the Study:
- To investigate serum osteocalcin and urine calcium/creatinine levels as markers of bone turnover in hyperthyroid patients.
- To compare these markers before and after antithyroid therapy, correlating with hyperthyroid and euthyroid states.
Main Methods:
- Assessed serum osteocalcin, alkaline phosphatase, calcium, phosphorus, Free T3, Free T4, TSH, and urine calcium/creatinine.
- Collected samples from 24 hyperthyroid patients and 20 healthy controls before and after treatment.
Main Results:
- Serum osteocalcin, urine calcium/creatinine, and serum phosphorus levels significantly decreased from hyperthyroid to euthyroid states.
- Elevated osteocalcin (bone formation) and urine calcium/creatinine (bone resorption) in hyperthyroidism confirm high bone turnover.
- These markers remained elevated even after achieving euthyroid status.
Conclusions:
- Hyperthyroid patients exhibit high bone turnover, involving both formation and resorption, which persists even after reaching euthyroidism.
- Serum osteocalcin and urine calcium/creatinine are sensitive indicators of bone remodeling during hyperthyroidism treatment.