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Related Experiment Videos

Prophylactic strategies before solid-organ transplantation.

Robin K Avery1

  • 1Department of Infectious Disease and Transplant Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. averyr@ccf.org

Current Opinion in Infectious Diseases
|July 9, 2004
PubMed
Summary

Pretransplant screening and management are crucial for preventing infections in organ transplant recipients. Recent findings impact donor screening for bacterial, fungal, and viral pathogens, guiding future prophylactic strategies and highlighting the need for more clinical trials.

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Area of Science:

  • Infectious Diseases
  • Transplantation Medicine
  • Epidemiology

Background:

  • Prophylactic measures in organ transplantation are evolving due to emerging infectious diseases and a better understanding of known infections.
  • Pretransplant screening and management are critical for reducing post-transplant infection risks.

Purpose of the Study:

  • To review recent developments impacting donor and recipient screening and pretransplant management.
  • To highlight key findings in bacterial, fungal, and viral infections relevant to organ transplantation.

Main Methods:

  • Literature review of recent reports and studies on infectious diseases in organ transplantation.
  • Analysis of findings related to donor and recipient screening and prophylactic strategies.

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Main Results:

  • Mupirocin decolonization lacks utility for Staphylococcus aureus prevention post-liver transplant.
  • Transmission of Pseudomonas, human herpesvirus-8, human T-cell lymphotropic virus-1, and West Nile virus from donors to recipients reported.
  • Emerging non-Candida albicans yeast and non-Aspergillus mold infections necessitate updated prophylactic strategies.
  • Increased understanding of Aspergillus colonization in cystic fibrosis patients and BK polyomavirus (BKV) allograft nephropathy.

Conclusions:

  • The pretransplant phase is vital for screening and intervention to minimize post-transplant infections.
  • Recent findings enhance understanding of infection epidemiology and risk stratification.
  • Further randomized trials are necessary to refine pretransplant protocols.