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Related Experiment Videos

Ciprofloxacin-resistant bacterial keratitis.

M E Snyder1, H R Katz

  • 1Krieger Eye Institute, Department of Ophthalmology, Sinai Hospital of Baltimore, MD 21215-5271.

American Journal of Ophthalmology
|September 15, 1992
PubMed
Summary

Ciprofloxacin is a common treatment for bacterial keratitis. However, some bacterial corneal ulcers may be resistant, necessitating alternative antimicrobial therapies guided by culture results.

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Area of Science:

  • Ophthalmology
  • Microbiology
  • Pharmacology

Background:

  • Ciprofloxacin ophthalmic solution (3 mg/ml) is a broad-spectrum antibiotic widely used for bacterial keratitis.
  • It has become a first-line treatment due to its efficacy against many gram-positive and gram-negative bacteria.

Observation:

  • Three patients presented with bacterial corneal ulcers.
  • These ulcers were resistant to ciprofloxacin treatment.

Findings:

  • Alternative topical antimicrobial agents successfully treated the ciprofloxacin-resistant corneal ulcers.
  • Initial microbiological culture results were crucial for guiding effective therapy.

Implications:

  • This highlights the importance of susceptibility testing in managing bacterial keratitis.
  • Clinicians should consider alternative agents when ciprofloxacin fails to resolve corneal infections.

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