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Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis
Luis Escribano1, Andrés Garca-Montero, Rosa Núñez-López
1Unidad de Mastocytosis, Laboratorio K. Frank Austen, Hospital Ramón y Cajal, Madrid, Spain. lescribano.hrc@salud.madrid.org
Abstract:
Mastocytosis may be associated with clonal nonmast cell lineage hematologic diseases, including myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Here we present a patient with the simultaneous diagnosis of mastocytosis and an acute myeloid leukemia, M2 subtype in the French-American-British classification, with t(8;21) carrying a population of immature mast cell precursors, and discuss this presentation in the context of a potential pathogenetic cellular link between this leukemia and mastocytosis.
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