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Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System
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Cyclin-dependent kinases regulate the antiproliferative function of Smads

Isao Matsuura1, Natalia G Denissova, Guannan Wang

  • 1Center for Advanced Biotechnology and Medicine,Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.

Nature
|July 9, 2004
PubMed
Summary

Cyclin-dependent kinases (CDKs) phosphorylate Smad3, inhibiting its growth-suppressing activity. This CDK-mediated inhibition of Smad3 may drive cancer development and resistance to transforming growth factor-beta (TGF-beta).

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