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Published on: September 26, 2018
Emergence of the concept of cardiovascular disease
1Renal Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030-3498, USA. geknoyan@bcm.tmc.edu
Insights
Cardiovascular disease was historically rare, with its study beginning in the 17th century. Key discoveries in the 19th and 20th centuries led to understanding hypertension and vascular lesions, significantly impacting modern medicine.
Area of Science:
- Medical History
- Cardiology
- Vascular Medicine
Background:
- Cardiovascular diseases were historically considered rare medical conditions.
- Early understanding of circulation by William Harvey in 1628 initiated scientific inquiry.
- The heart became a specific focus of study in the 19th century.
Observation:
- Richard Bright's 1827 description of kidney disease spurred vascular studies.
- Recognition of hypertension and vascular lesions like arteriosclerosis and atherosclerosis followed.
- The significant impact of these vascular lesions on mortality and morbidity was recognized between the World Wars.
Findings:
- The historical evolution of cardiovascular disease concepts is traced.
- Key milestones in understanding cardiac and vascular pathology are highlighted.
- The development of diagnostic and therapeutic approaches to cardiovascular conditions is outlined.
Implications:
- The study of vascular diseases profoundly reshaped 20th-century medicine.
- Understanding arteriosclerosis and atherosclerosis transformed patient care and outcomes.
- This historical perspective underscores the progress in cardiovascular medicine.
Abstract:
Historically, the concept of cardiovascular disease is a recent and evolving concept. Well into the eighteenth century, cardiac and vascular diseases were little known and considered a rarity. Description of the circulation by William Harvey (1578-1657) in 1628 marks the beginning of the changes that ensued. However, knowledge was slow to accrue and not until the nineteenth century was the heart taken as a specific object of study. The description of end-stage kidney disease by Richard Bright (1789-1858) in 1827 launched studies of the vasculature, which were to lead to the recognition of hypertension and subsequent identification of the lesions of arteriosclerosis (1833) and atherosclerosis (1904) as diseases of the vasculature. Only between the two world wars did the full impact of these lesions on mortality and morbidity come to be finally recognized. Their study and therapy has defined much of the profound changes that affected twentieth century medicine.
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