Related Experiment Video

Updated: Aug 23, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse
04:37

A Periprosthetic Joint Candida albicans Infection Model in Mouse

Published on: February 2, 2024

Prosthetic valve endocarditis due to Candida albicans treated successfully with medical treatment alone

Manabu Noguchi1, Hideaki Takai, Kiyoyuki Eishi

  • 1Department of Cardiovascular Surgery, Nagasaki Municipal Medical Center, Nagasaki, Japan.

The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai Zasshi
|July 10, 2004
PubMed

Insights

Prosthetic valve endocarditis (PVE) from Candida species poses risks. This case shows Candida PVE can be medically cured with antifungal therapy alone, avoiding surgery.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Mycology

Background:

  • Prosthetic valve endocarditis (PVE) caused by Candida species presents significant morbidity and mortality.
  • Current standard treatment involves surgical valve replacement combined with antifungal therapy.
  • Surgical intervention is not feasible for all patients with Candida PVE.

Observation:

  • A case of PVE caused by Candida albicans was successfully treated with medical management only.
  • The patient received antifungal drug therapy without surgical resection.

Findings:

  • Complete resolution of Candida PVE was achieved through antifungal therapy alone.
  • This outcome challenges the necessity of surgery in all Candida PVE cases.

Implications:

  • Medical management with antifungal therapy may be a viable alternative for select Candida PVE patients.
  • A conservative approach requires careful patient selection and intensive long-term monitoring.
  • Further research is warranted to define criteria for medical management of Candida PVE.

More Related Videos

A Catheter-Related Candida albicans Infection Model in Mouse03:24

A Catheter-Related Candida albicans Infection Model in Mouse

Published on: March 22, 2024

Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging08:31

Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging

Published on: January 27, 2015

Related Concept Videos

Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...