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Updated: Aug 23, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

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Published on: November 15, 2013

Nuclear receptors and disease: androgen receptor

Bruce Gottlieb1, Lenore K Beitel, Jianhui Wu

  • 1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montréal, Québec, Canada H3T 2E1. bruce.gottlieb@mcgill.ca

Essays in Biochemistry
|July 10, 2004
PubMed

Insights

Apoptosis, programmed cell death, is crucial for development and health. Dysregulation of apoptosis, whether excessive or insufficient, drives diseases like cancer and autoimmune disorders.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Pathology

Background:

  • Apoptosis (programmed cell death) is vital for organism development and maintaining tissue homeostasis.
  • Aberrant apoptosis, either excessive or deficient, is implicated in numerous human diseases.
  • Reduced apoptosis is a hallmark of cancer, while accelerated cell death contributes to autoimmune and inflammatory conditions.

Purpose of the Study:

  • To elucidate the dual role of apoptosis in health and disease.
  • To highlight the significance of apoptosis dysregulation in pathological processes.
  • To underscore the importance of understanding apoptosis for therapeutic interventions.

Main Methods:

  • Review of existing literature on apoptosis.
  • Analysis of molecular mechanisms underlying apoptosis regulation.
  • Correlation of apoptosis defects with disease pathologies.

Main Results:

  • Apoptosis is essential for normal development and tissue maintenance.
  • Imbalances in apoptosis contribute to tumorigenesis and autoimmune diseases.
  • Specific disease states are characterized by either resistance to or excessive induction of apoptosis.

Conclusions:

  • Apoptosis is a critical cellular process with profound implications for human health.
  • Understanding apoptosis dysregulation is key to developing treatments for cancer, autoimmune diseases, and inflammatory conditions.
  • Further research into apoptosis pathways may reveal novel therapeutic targets.

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