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Updated: Aug 17, 2026

Myo-mechanical Analysis of Isolated Skeletal Muscle
Published on: February 22, 2011
The effects of endurance training in persons with a hereditary myosin myopathy
K S Sunnerhagen1, N Darin, H Tajsharghi
1Department of Clinical Neuroscience-Rehabilitation Medicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. ks.sunnerhagen@neuro.gu.se
Objective:
To evaluate muscle performance and its consequences in eight individuals with a hereditary myopathy and the effects of an 8-week endurance training program.
Material And Methods:
Handgrip, muscle strength and endurance and oxygen consumption by breath-by-breath analysis during a stepless bicycle ergonometer test were evaluated. Walking, balance test and activities of daily living (ADL) were assessed, and a questionnaire for activity level and perceived symptoms was used. The design was a before-after trial in comparison with data from a control population, bicycling at 70% of maximal workload, 30 min/day, 5 days/week for 8 weeks.
Results:
The subjects were weaker than age-matched controls. After training, the peak watt increased by almost 20% (P < 0.05). Muscle strength (flexion/extension) and isometric endurance (40% of maximum at 60 degrees ) did not change significantly. The average self-selected walking speed increased significantly (P < 0.05) from 1.25 to 1.45 m/s. Compliance was excellent and no serious adverse events occurred.
Conclusion:
Endurance training seems to function for this myopathy.
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