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Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients
K Wada-Isoe1, Y Wakutani, K Urakami
1Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan. kewada@grape.med.tottori-u.ac.jp
Objectives:
To investigate a possible implication of inflammatory processes in the development of dementia in cerebrovascular disease.
Patients And Methods:
We examined the levels of interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) (n = 26), ischemic cerebrovascular disease without dementia (CVD) (n = 11), vascular dementia (VD) (n = 11), and other neurological disorders (n = 21) using sensitive enzyme-linked immunosorbent assay.
Results:
The CSF concentrations of IL-6 were significantly elevated in patients with VD compared with those of patients with AD or CVD.
Conclusion:
The CSF IL-6 levels are increased in patients with VD, suggesting that inflammatory mechanisms may be involved in the development of cognitive decline in some patients with cerebrovascular disease. CSF IL-6 may be a biological marker for dementia in cerebrovascular disease.
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