Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain plasticity and ion channels.

Dominique Debanne1, Gaël Daoudal, Valérie Sourdet

  • 1U464 INSERM Neurobiologie des Canaux Ioniques, Institut Fédératif Jean Roche, Faculté de Médecine Secteur Nord, Université d'Aix-Marseille II, 13916 Marseille, France. debanne.d@jean-roche.univ-mrs.fr

Journal of Physiology, Paris
|July 10, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Axon neurobiology: updates in functional and structural dynamics.

Frontiers in cellular neuroscience·2026
Same author

Unreliable homeostatic action potential broadening in cultured dissociated neurons.

bioRxiv : the preprint server for biology·2025
Same author

Visual activity enhances neuronal excitability in thalamic relay neurons.

Science advances·2025
Same author

Voltage-gated ion channels in epilepsies: circuit dysfunctions and treatments.

Trends in pharmacological sciences·2024
Same author

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus.

Journal of visualized experiments : JoVE·2024
Same author

cAMP reduces action potential amplitude and conduction velocity over long axonal distance.

The Journal of physiology·2024

Brain neurons use intrinsic plasticity, not just synaptic changes, to store memories. This involves persistent, regulated changes in ionic conductances, impacting signal propagation and forming memory engrams.

Area of Science:

  • Neuroscience
  • Cellular Neuroscience
  • Systems Neuroscience

Background:

  • Neuronal information processing relies on spatio-temporal activity patterns.
  • Synaptic plasticity is a known regulator, but intrinsic neuronal excitability also modulates information flow.
  • Persistent changes in ionic conductances offer another layer of regulation.

Purpose of the Study:

  • To review the role of neuronal activity in inducing intrinsic plasticity.
  • To explore mechanisms beyond synaptic plasticity in information coding.
  • To discuss the contribution of intrinsic plasticity to memory formation and neurological states.

Main Methods:

  • Review of existing literature on intrinsic plasticity in cortical, hippocampal, and cerebellar neurons.
  • Discussion of ionic channel properties and their role in neuronal excitability.

Related Experiment Videos

  • Analysis of the interplay between intrinsic and synaptic plasticity.

    • Main Results:

    • Neuronal activity, particularly via glutamate receptors, induces long-term changes in intrinsic excitability.
    • Intrinsic plasticity affects signal propagation in axons, dendrites, and soma.
    • These non-synaptic changes share induction pathways with synaptic plasticity and contribute to memory engrams.

    Conclusions:

    • Intrinsic plasticity is a crucial, non-synaptic mechanism for neuronal information processing and memory.
    • It complements synaptic plasticity, working in synergy to form memory engrams.
    • Understanding intrinsic plasticity is vital for comprehending learning, memory, and conditions like epilepsy.