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Updated: Aug 23, 2026
Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
Published on: March 26, 2015
Allograft maturation in anterior cruciate ligament reconstruction
Cassandra A Lee1, Jeffrey V Meyer, Jeffrey S Shilt
1Department of Orthopaedic Surgery, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA. calee@wfubmc.edu
Abstract:
This case report describes the histologic incorporation of a freeze-dried Achilles tendon allograft used for arthroscopic anterior cruciate ligament (ACL) reconstruction. The patient had regained stability from the procedure but had worsening pain over the medial compartment. The patient underwent total knee arthroplasty 2.5 years after ACL reconstruction. The surgeon was able to observe the graft in situ and examine the histology of the graft tunnel interface. This interface demonstrated Sharpey's fibers.
