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Updated: Aug 23, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection
Jun-ichi Kawada1, Hiroshi Kimura, Yoshinori Ito
1Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Abstract:
Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. To investigate the pathogenesis of neonatal HSV infection, we examined inflammatory responses and markers of apoptosis in patients with neonatal HSV infection. Concentrations of inflammatory cytokines and markers of apoptosis were significantly higher in patients with disseminated HSV infection and were correlated with HSV load. It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection.
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