Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hormonal Regulation

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice.

Journal of cachexia, sarcopenia and muscle·2026

Same author

Effects of separated pair housing of female C57BL/6JRj mice on well-being.

Scientific reports·2022

Same author

International consensus guidelines for surgery and the timing of intervention in chronic pancreatitis.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2019

Same author

Surveillance for pancreatic cancer in high-risk individuals.

BJS open·2019

Same author

[Directed evolution in drug and antibody development : From the Nobel Prize to broad clinical application].

Der Internist·2019

Same author

Letter to the editor: Insufficient Reporting of Randomization Procedures and Unexplained Unequal Allocation: A Commentary on "Dairy-Based and Energy-Enriched Berry-Based Snacks Improve or Maintain Nutritional and Functional Status in Older People in Home Care.

The journal of nutrition, health & aging·2019

Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026

Same journal

China boosts prestigious grants for young scientists - will it ease competition?

Nature·2026

Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026

Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026

Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026

Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 29, 2026

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

M Tschöp¹, T R Castañeda, H G Joost

¹Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA. tschoemh@ucmail.uc.edu

|July 13, 2004

Summary

This summary is machine-generated.

Replication of studies on the gut hormone PYY3-36, a potential obesity therapy, failed. These findings question the viability of PYY3-36 for anti-obesity treatments.

More Related Videos

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell

Published on: July 19, 2015

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Related Experiment Videos

Last Updated: Jun 29, 2026

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell

Published on: July 19, 2015

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Area of Science:

Endocrinology
Obesity Research
Gastrointestinal Hormones

Background:

The gut peptide hormone PYY3-36 was reported to reduce food intake and body weight in rodents.
This discovery suggested PYY3-36 as a potential novel therapy for obesity.

Discussion:

Replication of the original findings on PYY3-36's effects on food intake and body weight was unsuccessful.
The inability to reproduce the results raises concerns about the reliability of the initial study.
Discrepancies in findings highlight the need for further investigation into factors influencing PYY3-36 efficacy.

Key Insights:

The efficacy of PYY3-36 as an anti-obesity agent is currently uncertain due to failed replication.
An effective anti-obesity intervention must demonstrate consistent effects across various conditions.
The reproducibility of scientific results is crucial for validating therapeutic potential.

Outlook:

Further research is needed to understand the reasons for the conflicting results regarding PYY3-36.
Investigating the specific conditions and methodologies that influence PYY3-36's effects is essential.
The therapeutic potential of PYY3-36 for obesity management requires rigorous validation through reproducible studies.