Trisomy 16 confined to chorionic villi and unfavourable outcome of pregnancy

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G Simoni1, B Brambati, F Maggi

  • 1Cattedra di Genetica Umana, Istituto di Scienze Biomediche S. Paolo, Università degli Studi di Milano, Italy.

Annales De Genetique
|January 1, 1992
PubMed

Two cases of trisomy 16 confined to placental tissue associated with an unfavourable outcome of the pregnancy are reported. In the first case, after a diagnosis of an apparent non-mosaic trisomy 16 at chorionic villi sample (CVS), an intrauterine fetal death occurred at the 22nd week. In the second case a mosaic with trisomy 16 was found in chorionic villi and the fetus was still-born at 38 weeks. From a comparison of their cases with those of the literature, the authors conclude that a trisomy 16 confined to placental tissue has a negative effect on fetal growth and pregnancy outcome.

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