Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique.

M Valleri1, P Mura, F Maestrelli

  • 1Menarini Manufacturing Logistics and Services, Firenze, Italy.

Drug Development and Industrial Pharmacy
|July 13, 2004
PubMed
Summary

This study developed improved glyburide tablets using solid dispersion technology. The new tablets significantly enhance glyburide dissolution and bioavailability for better diabetes management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cyclodextrin complexation as a fruitful strategy for improving the performance of nebivolol delivery from solid lipid nanoparticles.

International journal of pharmaceutics·2024
Same author

Development and microbiological evaluation of chitosan and chitosan-alginate microspheres for vaginal administration of metronidazole.

International journal of pharmaceutics·2021
Same author

[Cannabis: Similarities and differences with tobacco].

Revue des maladies respiratoires·2020
Same author

Characterization and microbiological evaluation of chitosan-alginate microspheres for cefixime vaginal administration.

Carbohydrate polymers·2018
Same author

Assessing hand hygiene compliance among healthcare workers in six Intensive Care Units.

Journal of preventive medicine and hygiene·2017
Same author

Controlling catheter-related bloodstream infections through a multi-centre educational programme for intensive care units.

The Journal of hospital infection·2017

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Glyburide, an oral hypoglycemic agent, exhibits poor water solubility, leading to variable bioavailability and bio-inequivalence.
  • Addressing poor drug solubility is crucial for enhancing the efficacy of oral medications like glyburide.

Purpose of the Study:

  • To develop fast, reproducible, and complete glyburide dissolution from solid dispersion tablets.
  • To investigate the impact of various formulation and processing parameters on glyburide dissolution.

Main Methods:

  • Solid dispersions of glyburide in polyethylene glycol (PEG) were prepared using cofusion and coevaporation techniques.
  • Characterization involved phase-solubility studies, DSC, X-ray powder diffraction, and IR spectroscopy.

Related Experiment Videos

  • Tablet formulations were optimized considering preparation methods, drug-carrier ratio, PEG molecular weight, compression techniques, and particle size.

    • Main Results:

    • Tablets prepared by direct compression with larger solid dispersion particles (850-500 microm) and specific hardness (7-9 Kp) showed optimal performance.
    • The optimized formulation achieved a 135% increase in drug dissolution efficiency at 60 min compared to a reference tablet.
    • Dissolution profiles from the developed tablets outperformed various commercial glyburide formulations.

    Conclusions:

    • Solid dispersion of glyburide in PEG, particularly using the cofusion method, effectively enhances drug dissolution.
    • Optimized tablet formulation and direct compression are key to achieving superior glyburide bioavailability.
    • This approach offers a promising strategy for improving the therapeutic performance of poorly soluble drugs.