Characteristics of respiratory syncytial virus-related apnoea in three infants

M Rayyan1, G Naulaers, H Daniels

  • 1Department of Paediatrics, University Hospital Leuven, Leuven, Belgium. maissa.rayyan@uzleuven.be

Insights

Prolonged central apnoea in infants can be the initial indicator of respiratory syncytial virus (RSV) infection. This sign may appear before other symptoms or caregiver recognition of apnoea.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neonatology

Background:

  • Respiratory syncytial virus (RSV) is a common cause of respiratory infections in infants.
  • Apnoea is a recognized, though not universal, symptom of RSV infection.

Observation:

  • This study details polysomnographic findings in three infants with prolonged central apnoea.
  • These apnoeas occurred prior to the diagnosis of respiratory syncytial virus infection.
  • Caregivers did not report any apparent life-threatening events before the polysomnography.

Findings:

  • Polysomnography revealed central, prolonged apnoea in infants presenting with acquired RSV infection.
  • Apnoea was the primary presenting sign, preceding other respiratory symptoms.
  • No further apnoeas were detected upon cardiorespiratory monitoring post-infection.

Implications:

  • Central apnoea can be the sole presenting sign of RSV in young infants.
  • Early identification of RSV may be possible through monitoring for prolonged central apnoea.
  • This finding aids in understanding the diverse clinical presentations of RSV in neonates.
Abstract

Related Concept Videos

Respiratory Volumes and Capacities I01:26

Respiratory Volumes and Capacities I

Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
Alterations in Respiration II01:30

Alterations in Respiration II

There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes include...
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...