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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 11, 2013
Characteristics of respiratory syncytial virus-related apnoea in three infants
M Rayyan1, G Naulaers, H Daniels
1Department of Paediatrics, University Hospital Leuven, Leuven, Belgium. maissa.rayyan@uzleuven.be
Insights
Prolonged central apnoea in infants can be the initial indicator of respiratory syncytial virus (RSV) infection. This sign may appear before other symptoms or caregiver recognition of apnoea.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neonatology
Background:
- Respiratory syncytial virus (RSV) is a common cause of respiratory infections in infants.
- Apnoea is a recognized, though not universal, symptom of RSV infection.
Observation:
- This study details polysomnographic findings in three infants with prolonged central apnoea.
- These apnoeas occurred prior to the diagnosis of respiratory syncytial virus infection.
- Caregivers did not report any apparent life-threatening events before the polysomnography.
Findings:
- Polysomnography revealed central, prolonged apnoea in infants presenting with acquired RSV infection.
- Apnoea was the primary presenting sign, preceding other respiratory symptoms.
- No further apnoeas were detected upon cardiorespiratory monitoring post-infection.
Implications:
- Central apnoea can be the sole presenting sign of RSV in young infants.
- Early identification of RSV may be possible through monitoring for prolonged central apnoea.
- This finding aids in understanding the diverse clinical presentations of RSV in neonates.
Unlabelled:
Apnoea is a common sign in respiratory syncytial virus (RSV) infections in young infants and can be the first presentation of an acquired RSV infection. We describe polysomnographic recordings of three infants revealing prolonged RSV-related apnoea before RSV infection was diagnosed. The apnoeas were of central origin. The caregivers had not noted any apparent life-threatening events (ALTE) prior to the polysomnography. Cardiorespiratory monitoring after the acute infection did not reveal any further apnoeas.
Conclusion:
Central, prolonged apnoea can be the first sign of an acquired RSV infection in young infants in the absence of other respiratory symptoms and without any previous observation of apnoea by the caregivers.
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