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Related Experiment Videos

Controlled ultrasound tissue erosion.

Zhen Xu1, Achiau Ludomirsky, Lucy Y Eun

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. zhenx@umich.edu

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
|July 13, 2004
PubMed
Summary

Controlled ultrasound tissue erosion (CUTE) precisely perforates atrial walls. This noninvasive method shows promise for treating congenital heart defects like hypoplastic left heart syndrome, with successful in vivo canine trials.

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Area of Science:

  • Biomedical Engineering
  • Medical Ultrasound
  • Cardiovascular Surgery

Background:

  • Hypoplastic left heart syndrome (HLHS) requires interventions like atrial septum perforation.
  • Current procedures for atrial septum perforation can be invasive.
  • Developing noninvasive techniques is crucial for neonatal cardiac care.

Purpose of the Study:

  • To investigate controlled ultrasound tissue erosion (CUTE) for precise tissue perforation.
  • To evaluate CUTE as a noninvasive method for atrial septum perforation in HLHS treatment.
  • To explore parameters influencing CUTE's efficacy and energy efficiency.

Main Methods:

  • Utilized a 788 kHz single-element transducer to generate 232 perforations in porcine atrial walls.
  • Investigated effects of pulse repetition frequency (PRF), pulse duration (PD), and liquid gas content.

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  • Explored parameters including Isppa (9000 W/cm2), PDs (3-24 cycles), PRFs (1.34-66.7 kHz), and gas saturation (40-85%).

    • Main Results:

    • Optimized ultrasound parameters (short pulses at specific PRFs) maximized erosion rate and energy efficiency.
    • Demonstrated precise and well-defined perforations in atrial wall tissue using CUTE.
    • Successfully perforated the atrial septum in a preliminary in vivo canine experiment.

    Conclusions:

    • Controlled ultrasound tissue erosion (CUTE) offers a precise, noninvasive method for creating tissue perforations.
    • CUTE is a viable technique for atrial septum perforation, potentially revolutionizing HLHS treatment.
    • Further research and development of CUTE could lead to improved neonatal cardiac interventions.