Hodgkin's disease coexistent with plasma cell dyscrasia

We describe a case of Hodgkin's disease, mixed cellularity type, associated with nodal monotypic plasma cells and monoclonal serum gammopathy. Although plasma cells are often found in tissues involved by Hodgkin's disease and may be numerous, the occurrence of Hodgkin's disease with monotypic plasmacytosis and/or monoclonal serum gammopathy is rare. The simultaneous occurrence of Hodgkin's disease and monotypic plasma cell proliferation may represent a coincidental occurrence. However, previously we have described cases of Hodgkin's disease associated with B-cell non-Hodgkin's lymphoma, perhaps suggesting a relationship between the Reed-Sternberg and Hodgkin cells and B-lineage lymphoid cells. The case presented further extends these observations.