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Updated: Aug 23, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Metabolic and catheter complications of parenteral nutrition
Marwan S Ghabril1, Jamie Aranda-Michel, James S Scolapio
1Division of Gastroenterology and Hepatology, Mayo Clinic, 4500 San Pablo Drive, Jacksonville, FL 32224, USA.
Abstract:
Since its introduction in the 1960s, total parenteral nutrition (TPN) has played a vital role in improving clinical outcomes for patients with acute and chronic illnesses. The evolution of TPN solutions and vascular access techniques, combined with an increased awareness and better understanding of the physiology of TPN, have improved the safety of this therapy. Nevertheless, complications are not uncommon and can be life threatening. This article provides an updated review on the metabolic and catheter complications associated with TPN.
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