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Visualizing the immune response to pathogens
Aparna Srinivasan1, Stephen J McSorley
1Department of Medicine, Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030-1319, USA.
Abstract:
Advances in immune visualization have enabled the physical tracking of immune responses in vivo. The adaptation of such technology to models of infectious disease holds the promise of a more detailed analysis of host-pathogen interactions in a natural setting. However, the visualization of pathogen-specific immune responses in vivo confronts challenges that are inherent to the study of infectious disease systems. Recent attempts to track pathogen-specific immune responses in vivo validate the usefulness and underline the complexity of this experimental strategy.
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