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Heat-shock proteins and the host-pathogen interaction during bacterial infection
Graham R Stewart1, Douglas B Young
1Department of Infectious Diseases and Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. g.stewart@imperial.ac.uk
Current Opinion in Immunology
|July 13, 2004
Abstract:
Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.