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Updated: Aug 23, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Endothelial dysfunction in rheumatoid arthritis: influence of HLA-DRB1 alleles
Miguel A Gonzalez-Gay1, Carlos Gonzalez-Juanatey, William E Ollier
1Rheumatology Division, Hospital Xeral-Calde, Lugo 27004, Spain. miguelaggay@hotmail.com
Abstract:
Cardiovascular disease is the commonest cause of premature mortality in rheumatoid arthritis (RA) patients. Vascular endothelial injury is the primary event in atherosclerosis. It has been associated with endothelial dysfunction. We have recently observed that actively treated RA patients had endothelial dysfunction. HLA-DRB1 shared epitope alleles, in particular HLA-DRB1*0404, seem to be implicated in the development of endothelial dysfunction. These results underline the influence of genetic factors in the risk of atherosclerosis in RA patients.
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