Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

2-pyrones possessing antimicrobial and cytotoxic activities.

Ian J S Fairlamb1, Lester R Marrison, Julia M Dickinson

  • 1Department of Chemistry, University of York, Heslington, York YO10 5DD, UK. ijsf@york.ac.uk

Bioorganic & Medicinal Chemistry
|July 13, 2004
PubMed
Summary

Synthetic 2-pyrones were developed and tested for biological activity. Several compounds showed potent antimicrobial and anticancer effects, indicating potential as new therapeutic agents.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Site-Selective C-H Functionalization on Coumarins Directed by Manganese: Mechanistic Insights from Time-Resolved Spectroscopy and Catalytic Development.

ACS organic & inorganic Au·2026
Same author

Intramolecular Vibrational Energy Transfer in the Precatalyst [Mn(ppy)(CO)<sub>4</sub>] Tracked by Dual-Frequency 2D Infrared Spectroscopy.

The journal of physical chemistry. A·2026
Same author

Peptide modification <i>via</i> a mild carbonylative Suzuki-Miyaura reaction gives late-stage access to diaryl-ketones.

Chemical science·2026
Same author

Femtosecond-to-Second Time-Resolved Spectroscopy Brings Unparalleled Insight Into the Life Cycle of the Versatile Manganese Photocatalyst [Mn<sub>2</sub>(CO)<sub>10</sub>].

Journal of the American Chemical Society·2026
Same author

Extracting Mechanistic Information from an Open Data Set for a Pharma-Relevant Suzuki-Miyaura Cross-Coupling Reaction.

Organic process research & development·2026
Same author

Electrochemical Intermolecular Benzylic C(sp<sup>3</sup>)-H Imidation via Bromide-Mediated Cross-Dehydrogenative Coupling.

The Journal of organic chemistry·2026

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • The 2-pyrone scaffold is present in natural products with diverse biological activities.
  • These compounds interact with protein targets, leading to significant biological effects.
  • Identifying synthetic analogs with useful properties is an ongoing research area.

Purpose of the Study:

  • To synthesize novel 4-substituted-6-methyl-2-pyrones.
  • To evaluate their antimicrobial and anticancer activities.
  • To explore their potential as therapeutic agents.

Main Methods:

  • Development of synthetic routes using Sonogashira, Suzuki, and Negishi cross-coupling reactions.
  • Starting material: readily available 4-bromo-6-methyl-2-pyrone.

Related Experiment Videos

  • Optimization of reaction conditions for specific cross-coupling protocols.

    • Main Results:

    • Successfully synthesized a library of 4-alkyl/alkenyl/aryl/alkynyl-6-methyl-2-pyrones.
    • Demonstrated potent inhibitory activity against Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Schizosaccharomyces pombe, and Botrytis cinerea.
    • Selected 2-pyrones exhibited significant growth inhibition in A2780 ovarian carcinoma and K562 leukemia cell lines via MTT assay.

    Conclusions:

    • The synthesized 4-substituted-6-methyl-2-pyrones possess broad-spectrum antimicrobial properties.
    • Compounds like 4-phenylethynyl-, 4-tetrahydropyranylpropargyl ether-, and 4-ethynyl-6-methyl-2-pyrones show promise as novel anticancer agents.
    • This study highlights the therapeutic potential of synthetic 2-pyrone derivatives.