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Updated: Aug 23, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Lung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kong
Moira Chan-Yeung1, Kian Cheng Tan-Un, Mary Sau Man Ip
1Department of Medicine, Queen Mary Hospital, The University of Hong Kong, SAR, PR China. mmwchan@hkucc.hku.hk
Objective:
To study the potential role of genetic polymorphisms of glutathione-S-transferases GSTM1, GSTT1 and GSTP1 in susceptibility to lung cancer in Hong Kong Chinese.
Methods:
229 consecutive incident patients with a histological diagnosis of lung cancer from a regional hospital and 197 healthy population-based controls were recruited for this study between July 1999 and June 2001. Genetic polymorphisms of GSTT1 and GSTM1 were determined using PCR-based technique.
Results:
The frequencies of GSTT1 and GSTM1 null genotypes were 51.8 and 59.4% in healthy controls and 63 and 54.7%, respectively, in lung cancer patients. GSTP1 Val105/Val105 genotype was found in only 1% of healthy controls. The risk for lung cancer with GSTT1 null genotype was significantly higher, adjusted odds ratio (OR) 1.69, 95% confidence interval (CI) 1.12-2.56, compared with those with the GSTT1 genotype; the increase in risk was found only in non-smokers. GSTM1 null genotype, combined GSTT1 and GSTM1 null genotype and GSTP1 Val105/Val105 genotype did not confer any increase risk for lung cancer.
Conclusion:
GSTT1 null genotype is associated with an increased risk for lung cancer in non-smoking Chinese in Hong Kong.
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Single Nucleotide Polymorphisms-SNPs
